Progesterone Neuroprotection in traumatic CNS injury and motoneuron degeneration
- de Nicola, Alejandro Federico
- Labombarda, Maria Florencia
- Gonzalez Deniselle, Maria Claudia
- Gonzalez, Susana Laura
- Garay, Laura Ines
- Meyer, Maria
- Gargiulo Monachelli, Gisella Mariana
- Guennoun, Rachida
- Schummacher, Michale
DOIAbstract
Studies on the neuroprotective and promyelinating effects of progesterone in the nervous system are of great interest due to their potential clinical connotations. In peripheral neuropathies, progesterone and reduced derivatives promote remyelination, axonal regeneration and the recovery of function. In traumatic brain injury (TBI), progesterone has the ability to reduce edema and inflammatory cytokines, prevent neuronal loss and improve functional outcomes. Clinical trials have shown that short-and long-term progesterone treatment induces a significant improvement in the level of disability among patients with brain injury. In experimental spinal cord injury (SCI), molecular markers of functional motoneurons become impaired, including brai...
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