Endocytosis and intracellular traffic of cholesterol-PDMAEMA liposome complexes in human epithelial-like cells
- Szymanowski, Felipe
- Hugo, Ayelen Amelia
- Alves, P.
- Simões, P.N.
- Gomez Zavaglia, Andrea
- Perez, Pablo Fernando
DOIAbstract
Liposomes are generally used as delivery systems, as they are capable of encapsulating a wide variety of molecules (i.e. plasmids, recombinant proteins, therapeutic drugs). However, liposomal drug delivery have to fulfill different requirements, such as the effective internalization by the target cells and avoidance of the degradative activity of the intracellular compartments. The use of polymer lipid complexes (PLCs), by including different polymers in the liposome formulation, could improve internalization and intracellular release of drugs. The aim of the present work is to study the mechanisms of cellular uptaking and the intracellular trafficking of PLCs formed with cholesterol-poly(2-(dimethylamino)ethyl methacrylate) CHO-PDMAEMA and...
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