Body mass index and breast cancer survival: A Mendelian randomization analysis
- Guo, Qi
- Burgess, Stephen
- Turman, C. (Constance)
- Bolla, M.K. (Manjeet K.)
- Wang, Q. (Qin)
- Lush, M. (Michael)
- Abraham, Jean
- Aittomäki, Kristiina
- Andrulis, Irene
- Apicella, C. (Carmel)
- Arndt, V. (Volker)
- Barrdahl, Myrto
- Benítez, Javier
- Berg, Christine
- Blomqvist, Carl
- Bojesen, Stig
- Bonnani, Bernardo
- Brand, Judith S.
- Brenner, H. (Hermann)
- Broeks, Annegien
- Burwinkel, Barbara
- Caldas, Carlos
- Campa, Daniele
- Canzian, Federico
- Chang-Claude, Jenny
- Chanock, Stephen
- Chin, Suet-Feung
- Couch, F.J. (Fergus J.)
- Cox, Angela
- Cross, Simon
- Cybulski, Cezary
- Czene, Kamila
- Darabi, H. (Hatef)
- Devilee, Peter
- Diver, Ryan
- Dunning, Alison
- Earl, Helena
- Eccles, D.M. (Diana M.)
- Ekici, A.B. (Arif B.)
- Eriksson, Mats
- Evans, D.G. (D Gareth)
- Fasching, Peter
- Figueroa, Jonine
- Flesch-Janys, Dieter
- Flyger, Henrik
- Gapstur, Susan M.
- Gaudet, M.M. (Mia M.)
- Giles, G.G. (Graham G.)
- Glendon, G. (Gord)
- Grip, M. (Mervi)
- Gronwald, Jacek
- Haeberle, Lothar
- Haiman, Christopher
- Hall, Per
- Hamann, Ute
- Hankinson, Susan
- Hartikainen, J.M. (Jaana M.)
- Hein, A. (Alexander)
- Hiller, Louise
- Hogervorst, F.B. (Frans B.)
- Holleczek, B.
- Hooning, Maartje
- Hoover, Robert
- Humphreys, Keith
- Hunter, David
- Hüsing, Anika
- Jakubowska, Anna
- Jukkola-Vuorinen, A. (Arja)
- Kaaks, Rudolf
- Kabisch, M. (Maria)
- Kataja, Vesa
- Knight, Julia
- Koppert, Linetta
- Kosma, Veli-Matti
- Kristensen, V.N. (Vessela N.)
- Lambrechts, D. (Diether)
- Le Marchand, Loic
- Li, J. (Jingmei)
- Lindblom, Annika
- Lindström, S. (Sara)
- Lissowska, Jolanta
- Lubinski, Jan
- Machiela, Mitchell J.
- Mannermaa, Arto
- Manoukian, Siranoush
- Margolin, Sara
- Marme, F. (Federik)
- Martens, John
- McLean, Catriona Ann
- Menéndez, Primitiva
- Milne, Roger
- Mulligan, Anna-Marie
- Muranen, T.A. (Taru A.)
- Nevanlinna, Heli
- Neven, Patrick
- Nielsen, Sune F.
- Nordestgaard, Børge
- Olson, Janet
- Perez, Jose Ignacio Arias
- Peterlongo, Paolo
- Phillips, Kelly-Anne
- Poole, Christopher J.
- Pykäs, Katri
- Radice, Paolo
- Rahman, Nazneen
- Rud̈iger, Thomas
- Rudolph, A. (Anja)
- Sawyer, Elinor
- Schumacher, Fredrick R
- Seibold, P. (Petra)
- Seynaeve, Caroline
- Shah, M. (Mitul)
- Smeets, Ann
- Southey, M.C. (Melissa C.)
- Tollenaar, Rob
- Tomlinson, Ian
- Tsimiklis, Helen
- Ulmer, Hans
- Vachon, Celine
- Ouweland, Ans
- Veer, Laura
- Wildiers, Hans
- Willett, Walter C.
- Winqvist, Robert
- Zamora, Pilar
- Chenevix-Trench, Georgia
- Dörk, T. (Thilo)
- Easton, Douglas
- García-Closas, Montserrat
- Kraft, Peter
- Hopper, John
- Zheng, Wei
- Schmidt, Marjanka
- Pharoah, Paul
DOIAbstract
__Background:__ There is increasing evidence that elevated body mass index (BMI) is associated with reduced survival for women with breast cancer. However, the underlying reasons remain unclear. We conducted a Mendelian randomization analysis to investigate a possible causal role of BMI in survival from breast cancer. __Methods:__ We used individual-level data from six large breast cancer case-cohorts including a total of 36 210 individuals (2475 events) of European ancestry. We created a BMI genetic risk score (GRS) based on genotypes at 94 known BMI-associated genetic variants. Association between the BMI genetic score and breast cancer survival was analysed by Cox regression for each study separately. Study-specific hazard ratios were...
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