Agranulocytosis is a serious, although rare, adverse reaction to sulfasalazine, which is used to treat inflammatory joint and bowel disease. We performed a genome‐wide association study comprising 9,380,034 polymorphisms and 180 HLA alleles in 36 cases of sulfasalazine‐induced agranulocytosis and 5,170 population controls. Sulfasalazine‐induced agranulocytosis was significantly associated with the HLA region on chromosome 6. The top hit (rs9266634) was located close to HLA‐B, odds ratio (OR) 5.36 (95% confidence interval (CI) (2.97, 9.69) P = 2.55 × 10−8). We HLA‐sequenced a second cohort consisting of 40 cases and 142 treated controls, and confirmed significant associations with HLA‐B*08:01, OR = 2.25 (95% CI (1.02, 4.97) P = 0.0439), in p...
Background and Objective: Agranulocytosis is a rare and potentially life-threatening complication of...
[[sponsorship]]生物醫學科學研究所[[note]]出版中(accepted);[SCI];有審查制度;具代表性[[note]]http://gateway.isiknowledge.co...
We report the use of granulocyte-macrophage colony stimulating factor (GM-CSF) in a case of rheumato...
Agranulocytosis is a serious, although rare, adverse reaction to sulfasalazine, which is used to tre...
Agranulocytosis is a serious, although rare, adverse reaction to sulfasalazine, which is used to tre...
Agranulocytosis is a serious, although rare, adverse reaction to sulfasalazine, which is used to tre...
Agranulocytosis is a serious, although rare, adverse reaction to sulfasalazine, which is used to tre...
Background and Objective: Agranulocytosis is a rare and potentially life-threatening complication of...
Drug-induced agranulocytosis is a potentially life-threatening adverse reaction. Genome-wide associa...
Background and Objective: Agranulocytosis is a rare and potentially life-threatening complication of...
© 2015, The American Society for Clinical Pharmacology and Therapeutics.Thioamides antithyroid-drugs...
Thioamides antithyroid-drugs (ATDs) are important in hyperthyroid disease management. Identification...
Graves' disease is the leading cause of hyperthyroidism affecting 1.0-1.6% of the population. Antith...
Agranulocytosis is a rare yet severe idiosyncratic adverse drug reaction to metamizole, an analgesic...
Agranulocytosis is a rare yet severe idiosyncratic adverse drug reaction to metamizole, an analgesic...
Background and Objective: Agranulocytosis is a rare and potentially life-threatening complication of...
[[sponsorship]]生物醫學科學研究所[[note]]出版中(accepted);[SCI];有審查制度;具代表性[[note]]http://gateway.isiknowledge.co...
We report the use of granulocyte-macrophage colony stimulating factor (GM-CSF) in a case of rheumato...
Agranulocytosis is a serious, although rare, adverse reaction to sulfasalazine, which is used to tre...
Agranulocytosis is a serious, although rare, adverse reaction to sulfasalazine, which is used to tre...
Agranulocytosis is a serious, although rare, adverse reaction to sulfasalazine, which is used to tre...
Agranulocytosis is a serious, although rare, adverse reaction to sulfasalazine, which is used to tre...
Background and Objective: Agranulocytosis is a rare and potentially life-threatening complication of...
Drug-induced agranulocytosis is a potentially life-threatening adverse reaction. Genome-wide associa...
Background and Objective: Agranulocytosis is a rare and potentially life-threatening complication of...
© 2015, The American Society for Clinical Pharmacology and Therapeutics.Thioamides antithyroid-drugs...
Thioamides antithyroid-drugs (ATDs) are important in hyperthyroid disease management. Identification...
Graves' disease is the leading cause of hyperthyroidism affecting 1.0-1.6% of the population. Antith...
Agranulocytosis is a rare yet severe idiosyncratic adverse drug reaction to metamizole, an analgesic...
Agranulocytosis is a rare yet severe idiosyncratic adverse drug reaction to metamizole, an analgesic...
Background and Objective: Agranulocytosis is a rare and potentially life-threatening complication of...
[[sponsorship]]生物醫學科學研究所[[note]]出版中(accepted);[SCI];有審查制度;具代表性[[note]]http://gateway.isiknowledge.co...
We report the use of granulocyte-macrophage colony stimulating factor (GM-CSF) in a case of rheumato...