Super Resolution Techniques for Lab on Chip Application

Lab-on-a-chip systems are increasingly applied in cell-based assays for toxicology and drug testing. An on-chip integrated lens-less microscopy module using a direct projection method for optical monitoring of the shadow images of adherent growing mammalian cells is presented. The optical resolution of the assembly is estimated by the contact/proximate printing theory from optical lithography. Recently several alternative on-chip optical imaging techniques have been introduced, which have the potential to substitute conventional microscopes for various lab-on-a-chip applications. Multi-frame image super-resolution (SR) aims to utilize information from a set of low-resolution (LR) images to compose a high-resolution (HR) one. This set of algorithms commonly utilizes a linear observation model to construct the relationship between the recorded LR images to the unknown reconstructed HR image estimates. Recently, regularization-based schemes have been demonstrated to be effective because SR reconstruction is actually an ill-posed problem. Thorough experimental results show the effectiveness of the algorithm for SR reconstruction