Autoimmune Manifestations among Patients with Monogenic Inborn Errors of Immunity
- Azizi, G.
- Tavakol, M.
- Yazdani, R.
- Delavari, S.
- Moeini Shad, T.
- Rasouli, S. E.
- Jamee, M.
- Pashangzadeh, S.
- Kalantari, A.
- Shariat, M.
- Shafiei, A.
- Mohammadi, J.
- Hassanpour, G.
- Chavoshzadeh, Z.
- Mahdaviani, S. A.
- Momen, T.
- Behniafard, N.
- Nabavi, M.
- Bemanian, M. H.
- Arshi, S.
- Molatefi, R.
- Sherkat, R.
- Shirkani, A.
- Alyasin, S.
- Jabbari-Azad, F.
- Ghaffari, J.
- Mesdaghi, M.
- Ahanchian, H.
- Khoshkhui, M.
- Eslamian, M. H.
- Cheraghi, T.
- Dabbaghzadeh, A.
- Nasiri Kalmarzi, R.
- Esmaeilzadeh, H.
- Tafaroji, J.
- Khalili, A.
- Sadeghi-Shabestari, M.
- Darougar, S.
- Moghtaderi, M.
- Ahmadiafshar, A.
- Shakerian, B.
- Heidarzadeh, M.
- Ghalebaghi, B.
- Fathi, S. M.
- Darabi, B.
- Fallahpour, M.
- Mohsenzadeh, A.
- Ebrahimi, S.
- Sharafian, S.
- Vosughimotlagh, A.
- Tafakoridelbari, M.
- Rahimi Haji-Abadi, M.
- Ashournia, P.
- Razaghian, A.
- Rezaei, A.
- Salami, F.
- Shirmast, P.
- Bazargan, N.
- Mamishi, S.
- Ali Khazaei, H.
- Negahdari, B.
- Shokri, S.
- Nabavizadeh, S. H.
- Bazregari, S.
- Ghasemi, R.
- Bayat, S.
- Eshaghi, H.
- Rezaei, N.
- Abolhassani, H.
- Aghamohammadi, A.
DOIAbstract
BACKGROUND: The inborn errors of immunity (IEIs) are a group of heterogeneous disorders mainly characterized by severe and recurrent infections besides other complications including autoimmune and inflammatory diseases. In this study, we aim to evaluate clinical, immunological, and molecular data of monogenic IEI patients with and without autoimmune manifestations. METHODS: We have retrospectively screened cases of monogenic IEI in the Iranian PID registry for the occurrence of autoimmunity and immune dysregulation. A questionnaire was filled for all qualified patients with monogenic defects to evaluate demographic, laboratory, clinical, and molecular data. RESULTS: A total of 461 monogenic IEI patients (290 male and 171 female) with a medi...
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