Evaluation of [18F]-choline PET/CT for staging and restaging of prostate cancer

Purpose: To evaluate the accuracy of [18F]-choline (FCH) positron emission tomography/computed tomography (PET/CT) for staging and restaging of prostate cancer. Methods: FCH PET/CT was performed in 111 patients with prostate cancer using 200MBq FCH: 43 patients [mean age 63years; mean prostrate specific antigen (PSA) 11.58μg/l] were examined for initial staging, and 68 patients (mean age 66.4years) were examined for restaging (mean PSA 10.81μg/l). FCH PET/CT results were correlated to histopathology, bone scan, morphology as revealed by magnetic resonance imaging (MRI) and CT, PET/CT follow-up and PSA follow-up after therapy. Results: FCH PET/CT scans at initial staging correctly showed no metastases in 36/38 patients undergoing radical surgery, as confirmed by PSA levels 2μg/