Add to ORKGThe measurement of physicochemical properties at an early phase of drug discovery and development is crucial to reduce attrition rates due to poor biopharmaceutical properties. Among these properties, ionization, lipophilicity, solubility and permeability are mandatory to predict the pharmacokinetic behavior of NCEs (new chemical entities). Due to the high number of NCEs, the analytical tools used to measure these properties are automated and progressively adapted to high-throughput technologies. The present review is dedicated to experimental methods applied in the early drug discovery process for the determination of solubility, ionization constants, lipophilicity and permeability of small molecules. The principles and experimental condit...
The accurate prediction of solubility of drug-like molecules is difficult, and perhaps a satisfactor...
Physicochemical and pharmacokinetic profiling of new chemical entities (NCEs) allows the rapid ident...
The aim of this project was to develop a model for prediction of bioavailability of drug compounds f...
The measurement of physicochemical properties at an early phase of drug discovery and development is...
To enhance the attrition rate of drug candidates a rapid identification and elimination of compounds...
Phospholipophilicity, i.e. the affinity of a drug for phospholipids, is one of the key features modu...
New effective experimental techniques in medicinal chemistry and pharmacology have resulted in a vas...
The drug discovery process can be accelerated by chromatographic profiling of the analogs to model i...
A bioactive molecule must pass many hurdles to be designated as a good pharmaceutical lead or hit ...
The development of new drugs is a highly complex and expensive process, so it is crucial that less p...
The discovery and development of a new drug are time-consuming, difficult and expensive. This comple...
During the early phase of drug discovery, it is becoming increasingly important to acquire the full ...
New active pharmaceutical ingredients (APIs) continue to be discovered from the natural world. These...
The drug discovery and development pipeline have more and more relied on in vitro testing and in sil...
Objective: This research aims to observe the pharmacokinetic parameters that can be predicted using ...
The accurate prediction of solubility of drug-like molecules is difficult, and perhaps a satisfactor...
Physicochemical and pharmacokinetic profiling of new chemical entities (NCEs) allows the rapid ident...
The aim of this project was to develop a model for prediction of bioavailability of drug compounds f...
The measurement of physicochemical properties at an early phase of drug discovery and development is...
To enhance the attrition rate of drug candidates a rapid identification and elimination of compounds...
Phospholipophilicity, i.e. the affinity of a drug for phospholipids, is one of the key features modu...
New effective experimental techniques in medicinal chemistry and pharmacology have resulted in a vas...
The drug discovery process can be accelerated by chromatographic profiling of the analogs to model i...
A bioactive molecule must pass many hurdles to be designated as a good pharmaceutical lead or hit ...
The development of new drugs is a highly complex and expensive process, so it is crucial that less p...
The discovery and development of a new drug are time-consuming, difficult and expensive. This comple...
During the early phase of drug discovery, it is becoming increasingly important to acquire the full ...
New active pharmaceutical ingredients (APIs) continue to be discovered from the natural world. These...
The drug discovery and development pipeline have more and more relied on in vitro testing and in sil...
Objective: This research aims to observe the pharmacokinetic parameters that can be predicted using ...
The accurate prediction of solubility of drug-like molecules is difficult, and perhaps a satisfactor...
Physicochemical and pharmacokinetic profiling of new chemical entities (NCEs) allows the rapid ident...
The aim of this project was to develop a model for prediction of bioavailability of drug compounds f...