Metabolites derived from superoxide (o2 •−) and nitric oxide (NO•) play an important role in antimicrobial and antitumoral defense, but may also harm the host. Low levels of such metabolites can also facilitate viral replication because of their mitogenic effects on cells. Most viruses grow better in proliferating cells, and indeed, many viruses induced in their host cell changes similar to those seen early after treatment with mitogenic lectins. Influenza and paramyxoviruses activate in phagocytes the generation of superoxide by a mechanism involving the interaction between the viral surface glycoproteins and the phagocyte's plasma membrane. Interestingly, viruses that activate this host defense mechanism are toxic when injected in the blo...
AbstractMultiple viruses induce reactive oxygen intermediate (ROI) generation during infection that ...
Oxidative mechanisms are not only involved in chronic degenerative diseases but also in infectious d...
Cellular oxidoreductases catalyze thiol/disulfide exchange reactions in susceptible proteins and con...
Abstract Oxygen and nitrogen radicals are frequently produced during viral infections. These radical...
Viruses use cell machinery to replicate their genome and produce viral proteins. For this reason, se...
Reactive oxygen species (ROS) formation is part of normal cellular aerobic metabolism, due to respir...
The imminent threat of viral epidemics and pandemics dictates a need for therapeutic approaches that...
Virus-induced oxidative stress plays a critical role in the viral life cycle as well as the pathogen...
An appropriate level of reactive oxygen species (ROS) is necessary for cell proliferation, signaling...
Influenza A viral infections claim millions of lives worldwide and continue to impose a major burden...
Influenza viruses are deadly respiratory pathogens of special importance due to their long history o...
Nitric oxide (NO) has been shown to contribute to the pathogenesis of influenza virus-induced pneumo...
An overproduction of reactive oxygen species (ROS) mediated by NADPH oxidase 2 (NOX2) has been relat...
AbstractUpon stimulation murine macrophages produce high levels of nitric oxide (NO), a potent micro...
Viral, bacterial, and parasitic infections comprise a vast group of etiological agents that cause ac...
AbstractMultiple viruses induce reactive oxygen intermediate (ROI) generation during infection that ...
Oxidative mechanisms are not only involved in chronic degenerative diseases but also in infectious d...
Cellular oxidoreductases catalyze thiol/disulfide exchange reactions in susceptible proteins and con...
Abstract Oxygen and nitrogen radicals are frequently produced during viral infections. These radical...
Viruses use cell machinery to replicate their genome and produce viral proteins. For this reason, se...
Reactive oxygen species (ROS) formation is part of normal cellular aerobic metabolism, due to respir...
The imminent threat of viral epidemics and pandemics dictates a need for therapeutic approaches that...
Virus-induced oxidative stress plays a critical role in the viral life cycle as well as the pathogen...
An appropriate level of reactive oxygen species (ROS) is necessary for cell proliferation, signaling...
Influenza A viral infections claim millions of lives worldwide and continue to impose a major burden...
Influenza viruses are deadly respiratory pathogens of special importance due to their long history o...
Nitric oxide (NO) has been shown to contribute to the pathogenesis of influenza virus-induced pneumo...
An overproduction of reactive oxygen species (ROS) mediated by NADPH oxidase 2 (NOX2) has been relat...
AbstractUpon stimulation murine macrophages produce high levels of nitric oxide (NO), a potent micro...
Viral, bacterial, and parasitic infections comprise a vast group of etiological agents that cause ac...
AbstractMultiple viruses induce reactive oxygen intermediate (ROI) generation during infection that ...
Oxidative mechanisms are not only involved in chronic degenerative diseases but also in infectious d...
Cellular oxidoreductases catalyze thiol/disulfide exchange reactions in susceptible proteins and con...