Simple preparation of76Br,123I and211At labeled 5-halo-2′-deoxyuridine

A fast and easy method for the preparation of radiolabeled 5-halo-2′-deoxyuridine (halo=[76Br], [123I] and [211At]) is presented. Labeling is accomplished by oxidation of the halogenide with Iodogen for [123I] and [211At], and Chloramine-T (CAT) for [76Br] followed by halodestannylation of 5-trimethylstannyl-2′-deoxyuridine (TMSUdR). The reaction takes 1 minute giving >90% yield for all three halogen