Topics
oxaliplatinChemical substance
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mass spectrometryTopical concept
electrosprayTopical concept
adductSoftware
cisplatinChemical substance
tandem mass spectrometryTopical concept
DNABand
carboplatinChemical substance
guanineChemical substance
The binding of the ruthenium-based anticancer drug candidates KP1019, NAMI-A and RAPTA-T towards different double-stranded oligonucleotides was probed by electrospray ionisation mass spectrometry and compared with that of the widely used platinum-based chemotherapeutics cisplatin, carboplatin and oxaliplatin. It was found that the extent of adduct formation decreased in the following order: cisplatin>oxaliplatin>NAMI-A>RAPTA-T>carboplatin>KP1019. In addition to the characterisation of the adducts formed with the DNA models, the binding sites of the metallodrugs on the oligonucleotides were elucidated employing top-down tandem mass spectrometry and were found to be similar for all the metallodrugs studied, irrespective of the sequence of the...
DIGE (difference in gel electrophoresis) proteomics is exploited here to gain insight into the molec...
DIGE (difference in gel electrophoresis) proteomics is exploited here to gain insight into the molec...
DIGE (difference in gel electrophoresis) proteomics is exploited here to gain insight into the molec...
The binding of the ruthenium-based anticancer drug candidates KP1019, NAMI-A and RAPTA-T towards dif...
Electrospray ionisation mass spectrometry was used to analyse the reactions of metal compounds with ...
DNA is believed to be the primary target for many metal-based drugs. For example, platinum-based ant...
The aim of the study is to evaluate the differences of protein binding of NAMI-A, a new ruthenium dr...
The search for effective drugs against cisplatin-resistant tumors resulted in a large number of orga...
Cancer is one of the most common fatal diseases in humans nowadays. About 20 million new cancer case...
DIGE (difference in gel electrophoresis) proteomics is exploited here to gain insight into the molec...
Hybrid QM/MM calculations on adducts of five platinum-based anti-cancer drugs, namely cisplatin, oxa...
The cellular uptake and subcellular distribution including adduct formation with genomic DNA and upt...
Hybrid QM/MM calculations on adducts of five platinum-based anti-cancer drugs, namely cisplatin, oxa...
Hybrid QM/MM calculations on adducts of five platinum-based anti-cancer drugs, namely cisplatin, oxa...
DIGE (difference in gel electrophoresis) proteomics is exploited here to gain insight into the molec...
DIGE (difference in gel electrophoresis) proteomics is exploited here to gain insight into the molec...
DIGE (difference in gel electrophoresis) proteomics is exploited here to gain insight into the molec...
DIGE (difference in gel electrophoresis) proteomics is exploited here to gain insight into the molec...
The binding of the ruthenium-based anticancer drug candidates KP1019, NAMI-A and RAPTA-T towards dif...
Electrospray ionisation mass spectrometry was used to analyse the reactions of metal compounds with ...
DNA is believed to be the primary target for many metal-based drugs. For example, platinum-based ant...
The aim of the study is to evaluate the differences of protein binding of NAMI-A, a new ruthenium dr...
The search for effective drugs against cisplatin-resistant tumors resulted in a large number of orga...
Cancer is one of the most common fatal diseases in humans nowadays. About 20 million new cancer case...
DIGE (difference in gel electrophoresis) proteomics is exploited here to gain insight into the molec...
Hybrid QM/MM calculations on adducts of five platinum-based anti-cancer drugs, namely cisplatin, oxa...
The cellular uptake and subcellular distribution including adduct formation with genomic DNA and upt...
Hybrid QM/MM calculations on adducts of five platinum-based anti-cancer drugs, namely cisplatin, oxa...
Hybrid QM/MM calculations on adducts of five platinum-based anti-cancer drugs, namely cisplatin, oxa...
DIGE (difference in gel electrophoresis) proteomics is exploited here to gain insight into the molec...
DIGE (difference in gel electrophoresis) proteomics is exploited here to gain insight into the molec...
DIGE (difference in gel electrophoresis) proteomics is exploited here to gain insight into the molec...
DIGE (difference in gel electrophoresis) proteomics is exploited here to gain insight into the molec...
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