The Fas receptor is involved in the regulation of apoptosis but also can function as a non-apoptotic signal transducer. This study was mainly designed to quantitate Fas proteins in rat brain during heroin addiction and opiate withdrawal. In rat, mouse and human brains, and in SH-SY5Y cells, similar forms of Fas were immunodetected with different antibodies (i.e., 35kDa native Fas and 48- and 51-kDa glycosylated Fas). Acute (2h) treatments with the μ-opioid receptor agonists heroin (10mg/kg) and morphine (30mg/kg) increased the immunodensity of native Fas (124% and 36%) but not that of glycosylated Fas in the cerebral cortex. Chronic (5days) heroin (5-30mg/kg) and morphine (10-100mg/kg) were also associated with increased native Fas (76% and...
Abstinence from chronic morphine results in characteristic withdrawal symptoms in humans and experim...
Abstinence from chronic morphine results in characteristic withdrawal symptoms in humans and experim...
Although morphine is one of the most effective analgesics available, its long-term use is severely l...
[eng] This study was designed to assess the effects of opiate treatment on the expression of Fas-ass...
[eng] This study was designed to immunodetect and characterize Fas receptor aggregates (oligomerizat...
[eng] The acute effects of opiate drugs and opiate addiction have been associated with modulation of...
The acute effects of opiate drugs and opiate addiction have been associated with modulation of Fas/F...
[eng] Opioid drugs have been proposed to promote anti-apoptotic signals in brain through inhibition ...
Opiate addiction is a chronic medical disorder characterized by drug tolerance and dependence, behav...
[eng] This study was designed to assess the influence of activation and blockade of the endogenous o...
Fas-associated protein with death domain (FADD) is a multifunctional protein that can induce both ap...
Opioids such as heroin are highly addictive illicit drugs. The μ opioid receptor (MOR) plays a centr...
AbstractRats made dependent on heroin and morphine exhibit both qualitative and quantitative differe...
One of the most troubling aspects of addiction is the chronic and cyclical nature of this disorder. ...
Opiate addiction is characterized by drug tolerance and dependence which involve adaptive changes in...
Abstinence from chronic morphine results in characteristic withdrawal symptoms in humans and experim...
Abstinence from chronic morphine results in characteristic withdrawal symptoms in humans and experim...
Although morphine is one of the most effective analgesics available, its long-term use is severely l...
[eng] This study was designed to assess the effects of opiate treatment on the expression of Fas-ass...
[eng] This study was designed to immunodetect and characterize Fas receptor aggregates (oligomerizat...
[eng] The acute effects of opiate drugs and opiate addiction have been associated with modulation of...
The acute effects of opiate drugs and opiate addiction have been associated with modulation of Fas/F...
[eng] Opioid drugs have been proposed to promote anti-apoptotic signals in brain through inhibition ...
Opiate addiction is a chronic medical disorder characterized by drug tolerance and dependence, behav...
[eng] This study was designed to assess the influence of activation and blockade of the endogenous o...
Fas-associated protein with death domain (FADD) is a multifunctional protein that can induce both ap...
Opioids such as heroin are highly addictive illicit drugs. The μ opioid receptor (MOR) plays a centr...
AbstractRats made dependent on heroin and morphine exhibit both qualitative and quantitative differe...
One of the most troubling aspects of addiction is the chronic and cyclical nature of this disorder. ...
Opiate addiction is characterized by drug tolerance and dependence which involve adaptive changes in...
Abstinence from chronic morphine results in characteristic withdrawal symptoms in humans and experim...
Abstinence from chronic morphine results in characteristic withdrawal symptoms in humans and experim...
Although morphine is one of the most effective analgesics available, its long-term use is severely l...