Published online: 9 May 2018Caspases, a family of cysteine-dependent aspartate-specific proteases, are central to the maintenance of cellular and organismal homoeostasis by functioning as key mediators of the inflammatory response and/or apoptosis. Both metabolic inflammation and apoptosis play a central role in the pathogenesis of metabolic disease such as obesity and the progression of nonalcoholic steatohepatisis (NASH) to more severe liver disease. Obesity and nonalcoholic fatty liver disease (NAFLD) are the leading global health challenges associated with the development of numerous comorbidities including insulin resistance, type-2 diabetes and early mortality. Despite the high prevalence, current treatment strategies including lifest...
Abstract: Non-alcoholic steatohepatitis (NASH) is a severe form of non-alcoholic fatty liver disease...
Mapping of the human and other eukaryotic genomes has provided the pharmacological industry with exc...
ABSTR ACT: Apoptosis is physiological cell death required for the cellular maintenance of homeostasi...
BACKGROUND/OBJECTIVES: Non-alcoholic steatohepatitis (NASH) is a serious liver condition, closely as...
<p>Non-alcoholic fatty liver disease (NAFLD) is now the most common liver disorder in Western countr...
International audienceOBJECTIVE: Caspase-2 is an initiator caspase involved in multiple apoptotic pa...
Background: From their initial, accidental discovery 50 years ago, the highly conserved Heat Shock P...
Caspases are an evolutionary conserved family of cysteine proteases that are centrally involved in c...
Abstract Caspases are an evolutionary conserved family of cysteine-dependent proteases that are invo...
BACKGROUND & AIMS: Hepatocyte apoptosis, the hallmark of non-alcoholic steatohepatitis (NASH) contri...
: nonalcoholic steatohepatitis (NASH) is a globally emerging health problem, mainly caused by increa...
In human and murine models of nonalcoholic steatohepatitis (NASH), increased hepatocyte apoptosis is...
The development of small molecules to modulate caspase activity offers a novel therapeutic strategy ...
Abstract. Caspases are crucial mediators of apoptosis, a form of physiological cell death. Their act...
1. Apoptosis is an essential process to remove excess, unwanted and harmful cells and maintain homeo...
Abstract: Non-alcoholic steatohepatitis (NASH) is a severe form of non-alcoholic fatty liver disease...
Mapping of the human and other eukaryotic genomes has provided the pharmacological industry with exc...
ABSTR ACT: Apoptosis is physiological cell death required for the cellular maintenance of homeostasi...
BACKGROUND/OBJECTIVES: Non-alcoholic steatohepatitis (NASH) is a serious liver condition, closely as...
<p>Non-alcoholic fatty liver disease (NAFLD) is now the most common liver disorder in Western countr...
International audienceOBJECTIVE: Caspase-2 is an initiator caspase involved in multiple apoptotic pa...
Background: From their initial, accidental discovery 50 years ago, the highly conserved Heat Shock P...
Caspases are an evolutionary conserved family of cysteine proteases that are centrally involved in c...
Abstract Caspases are an evolutionary conserved family of cysteine-dependent proteases that are invo...
BACKGROUND & AIMS: Hepatocyte apoptosis, the hallmark of non-alcoholic steatohepatitis (NASH) contri...
: nonalcoholic steatohepatitis (NASH) is a globally emerging health problem, mainly caused by increa...
In human and murine models of nonalcoholic steatohepatitis (NASH), increased hepatocyte apoptosis is...
The development of small molecules to modulate caspase activity offers a novel therapeutic strategy ...
Abstract. Caspases are crucial mediators of apoptosis, a form of physiological cell death. Their act...
1. Apoptosis is an essential process to remove excess, unwanted and harmful cells and maintain homeo...
Abstract: Non-alcoholic steatohepatitis (NASH) is a severe form of non-alcoholic fatty liver disease...
Mapping of the human and other eukaryotic genomes has provided the pharmacological industry with exc...
ABSTR ACT: Apoptosis is physiological cell death required for the cellular maintenance of homeostasi...