The Effects of Channa Striatus Extract Administration on Wound Healing Markers (il-6, Mmp-9 and Vegf) in Post Lower Segment Caesarean Section (lscs) Women

Channa Striatus (Haruan) digunakan secara meluas di Malaysia untuk menggalakkan penyembuhan luka. Sejak turun temurun, C.striatus telah dipercayai mempunyai sifat anti-radang, anti-oksida dan anti sakit untuk penyembuhan luka yang lebih baik. Penyembuhan luka adalah satu proses dinamik yang melibatkan empat fasa yang berbeza namun berlaku secara serentak dan bertindih iaitu hemostasis, keradangan, percambahan dan pembentukan semula tisu. Proses yang sangat rumit ini bermula dengan serta-merta selepas kecederaan dan melibatkan tindakbalas yang tersusun antara pelbagai jenis tisu-tisu dan sel-sel. Di dalam proses penyembuhan ini, leukosit, makrophaj dan sel endothelial akan mengeluarkan pelbagai faktor-faktor pertumbuhan dan sitokin seperti Interleukin 6 (IL-6), Matrix Metalloproteinase-9 (MMP-9) dan Vascular Endothelial Growth Factor (VEGF). IL- 6 mengawal penghasilan leukosit ke kawasan inflammasi. Channa striatus (ikan haruan) is widely consumed in Malaysia to promote wound healing. For centuries, C.striatus has been proposed to have antiinflammatory, anti-oxidant and anti-nociceptive properties for better healing of the wound. Wound healing is a dynamic process that involves four disticnt yet an overlapping phases; haemostasis, inflammation, proliferation and tissue remodeling. It starts immediately after injury and proceeds with a complicated but well-organized interaction among various types of tissues and cells. During wound healing process, leukocytes, macrophages and endothelial cell release various growth factors and cytokines such as interleukin 6 (IL-6), matrix metalloproteinase 9 (MMP-9) and vascular endothelial growth factor (VEGF). IL-6 regulates leukocytes recruitment to the inflammatory sites