Lymph node ratio as a prognostic factor in melanoma: Results from European Organization for Research and Treatment of Cancer 18871, 18952, and 18991 studies

Testori, Alessandro
Suciu, Stefan
van Akkooi, Alexander A.C.J.
Suppa, Mariano
Eggermont, A.M.M.
De Vries, Esther
Joosse, A.

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Publication date

January 2018

DOI

10.1097/CMR.0000000000000433

Publisher

Ovid Technologies (Wolters Kluwer Health)

Abstract

The aim of this study was to assess the prognostic importance of lymph node ratio (LNR) in stage III melanoma after complete lymph nodal dissections. From European Organization for Research and Treatment of Cancer randomized trials 18871, 18952, and 18991, 2358 patients had full information on positive and examined lymph nodes (LNs) and were included. Cox proportional hazards models stratified by trial were used to assess the prognostic impact of LNR adjusted for confounders on melanoma-specific survival. Optimal cutoff values for LNR were calculated for each LN dissection site (axillary, inguinal, and neck). LNR (≥ vs. <35%: Hazard ratio=1.44, 95% confidence interval: 1.23-1.69) and number of positive LNs appeared to be of independent stro...

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Lymph node ratio as a prognostic factor in melanoma: Results from European Organization for Research and Treatment of Cancer 18871, 18952, and 18991 studies

Abstract

Extracted data

Lymph node ratio as a prognostic factor in melanoma: Results from European Organization for Research and Treatment of Cancer 18871, 18952, and 18991 studies

Abstract

Extracted data

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