Postoperative kidney function in Japanese living kidney donors

Few investigations about safety of post-donation living kidney donors have been conducted,especially in Japanese. I reviewed medical records of 1519 living kidney donors who donated inTokyo women’s medical university hospital. Using all the data or partially, I investigated theirpost-donation trends in glomerular filtration rate (GFR) and risk for kidney disease such aspersistent proteinuria or progressive renal dysfunction, and end-stage renal disease (ESRD). Most(> 90%) donors developed GFR corresponding to chronic kidney disease (CKD) stage3, however,showed stabilized trends in GFR until 3 years after donation, distinct from those of CKD patients inthe general population. Meanwhile, donors who developed ESRD had maintained GFR for longperiod, but which started to decline after having comorbidities known as progression factors ofCKD. They had higher incidence of protenuria, acute cardiovascular events, severe infection, andhospitalization due to accelerating factors of CKD than those not developing ESRD. Furthermore,donors having persistent glomerular hematuria both pre- and post-donation had significantly higherrisk for kidney disease after donation. Kidney donors might be inappropriate for labeling as CKD,however, they should be carefully evaluated and followed for long period with attention on CKDrisk factors, especially those with glomerular hematuria.報告番号: 甲25979 ; 学位授与年月日: 2010-03-24 ; 学位の種別: 課程博士 ; 学位の種類: 博士(医学) ; 学位記番号: 博医第3458号 ; 研究科・専攻: 医学系研究科内科学専