The effect of life course socioeconomic position on crystallised cognitive ability in two large UK cohort studies: a structured modelling approach.

OBJECTIVES: This study systematically compared accumulation, sensitive period, critical period and social mobility models relating life course socioeconomic position (SEP) and adult crystallised cognitive ability, which has not been comprehensively investigated. DESIGN: Two prospective cohort studies. PARTICIPANTS: Five thousand three hundred and sixty-two participants in the Medical Research Council National Survey of Health and Development (NSHD) Birth Cohort Study and 10 308 participants in the Whitehall II Occupational Cohort Study. MEASURES: Childhood SEP was measured by father's occupational SEP, early adulthood SEP by educational qualifications and adult SEP by own occupational SEP. Each life course model was compared with a saturated model. RESULTS: Using multiple imputation to account for missing data, the sensitive period model, which contained childhood, early adulthood and adult SEP terms, with different coefficients, provided the best fit for both men and women in the NSHD and Whitehall II cohorts. Early adulthood SEP had the largest coefficient in NSHD women, whereas for NSHD men early adulthood and adult SEP had similar coefficients. In Whitehall II adult SEP had the largest effect size for both men and women. CONCLUSIONS: Sensitive period with all three time periods was the most appropriate life course models for adult crystallised cognitive ability in both cohorts, including an effect of childhood SEP. It is important to directly compare the life course models to determine which is the most appropriate.RL was supported by an ESRC PhD studentship at University College London. The UK Medical Research Council, British Heart Foundation and the US National Institutes of Health(R01HL36310, R01AG013196) have supported collection of data in the Whitehall II Study. JH is partially supported by the Economic and Social Research Council (ES/K01336X/1). The MRC National Survey of Health and Development, MR and RH are funded by the UK Medical Research Council (MC_UU_12019/1, MC_UU_12019/2, MC_UU_12019/3)