Crystal shape modification via cycles of growth and dissolution in a tubular crystallizer
- Neugebauer, Peter
- Cardona, Javier
- Besenhard, Maximilian O.
- Peter, Anna
- Gruber-Woelfler, Heidrun
- Tachtatzis, Christos
- Cleary, Alison
- Andonovic, Ivan
- Sefcik, Jan
- Khinast, Johannes G.
DOIAbstract
Besides size and polymorphic form, crystal shape takes a central role in engineering advanced solid materials for pharmaceutical and chemical industry. This work demonstrates how multiple cycles of growth and dissolution can manipulate the habit of an acetylsalicylic acid crystal population. Considerable changes of the crystal habit could be achieved within minutes due to rapid cycling, i.e., up to 25 cycles within <10 min. The required fast heating and cooling rates were facilitated using a tubular reactor design allowing for superior temperature control. The face specific interactions between solvent and the crystals’ surface result in face specific growth and dissolution rates and hence alterations of the final shape of the crystals in s...
Add to ORKG