Piezo1 proteins are Na+ and Ca2+ permeable mechanosensitive ion channels. Expressed on endothelial cell membranes, where they sense the shear stress forces created by blood flow, Piezo1 channels are essential for vascular development. The functional significance of vascular Piezo1 channels in adult physiology and pathology, however, remains largely unexplored. Therefore, using an inducible, endothelial-specific Piezo1 knock-out mouse line this study sought to identify and investigate the functional role of this channel in adult arterial vessels. Four morphologically and physiologically distinct arteries, the aorta, mesenteric, saphenous and carotid arteries, were selected and their responses to the vasoconstrictor phenylephrine (PE) and the...
Arterial blood pressure is controlled by vasodilatory factors such as nitric oxide (NO) that are rel...
Endogenous PIEZO1 channels of native endothelium lack the hallmark inactivation often seen when thes...
Piezo1 is a mechanosensitive cation channel with widespread physiological importance; however, its r...
Mammalian biology adapts to physical activity but the molecular mechanisms sensing the activity rema...
The mechanisms by which physical forces regulate endothelial cells to determine the complexities of ...
Piezo1 channels are newly discovered ion channels which have come to the fore as players in endothel...
Piezo proteins are transmembrane ion channels, specialized in detecting mechanosensitive stimuli and...
In intrapulmonary artery (IPA), endothelial cells (EC) respond to mechanical stimuli by releasing va...
International audienceMechanotransduction plays a key role in vascular development, physiology and d...
Mechanical forces are fundamental in cardiovascular biology, and deciphering the mechanisms by which...
Piezo1 forms mechanically-activated non-selective cation channels that contribute to endothelial res...
SummaryThe mechanically activated non-selective cation channel Piezo1 is a determinant of vascular a...
Mechanosensation is perhaps the last sensory modality not understood at the molecular level. Ion cha...
Shafiu A Umar Shinge, 1 Daifang Zhang, 1, 2 Tobias Achu Muluh, 3 Yongmei Nie, 1, 4 Fengxu Yu 1, 4 1...
Mechanosensitive ion channels mediate endothelial responses to blood flow and orchestrate their phys...
Arterial blood pressure is controlled by vasodilatory factors such as nitric oxide (NO) that are rel...
Endogenous PIEZO1 channels of native endothelium lack the hallmark inactivation often seen when thes...
Piezo1 is a mechanosensitive cation channel with widespread physiological importance; however, its r...
Mammalian biology adapts to physical activity but the molecular mechanisms sensing the activity rema...
The mechanisms by which physical forces regulate endothelial cells to determine the complexities of ...
Piezo1 channels are newly discovered ion channels which have come to the fore as players in endothel...
Piezo proteins are transmembrane ion channels, specialized in detecting mechanosensitive stimuli and...
In intrapulmonary artery (IPA), endothelial cells (EC) respond to mechanical stimuli by releasing va...
International audienceMechanotransduction plays a key role in vascular development, physiology and d...
Mechanical forces are fundamental in cardiovascular biology, and deciphering the mechanisms by which...
Piezo1 forms mechanically-activated non-selective cation channels that contribute to endothelial res...
SummaryThe mechanically activated non-selective cation channel Piezo1 is a determinant of vascular a...
Mechanosensation is perhaps the last sensory modality not understood at the molecular level. Ion cha...
Shafiu A Umar Shinge, 1 Daifang Zhang, 1, 2 Tobias Achu Muluh, 3 Yongmei Nie, 1, 4 Fengxu Yu 1, 4 1...
Mechanosensitive ion channels mediate endothelial responses to blood flow and orchestrate their phys...
Arterial blood pressure is controlled by vasodilatory factors such as nitric oxide (NO) that are rel...
Endogenous PIEZO1 channels of native endothelium lack the hallmark inactivation often seen when thes...
Piezo1 is a mechanosensitive cation channel with widespread physiological importance; however, its r...