Cyclooctyne [60]fullerene hexakis adducts: a globular scaffold for copper-free click chemistry

The synthesis of a new highly symmetric hexakis adduct of C60 appended with 12 cyclooctyne moieties has been carried out. This compound has been used for the copper-free strain-promoted cycloaddition reaction to a series of azides with excellent yields. This strategy for the obtention of clicked adducts of [60]fullerene is of special interest for biological applicationsEuropean Research Council ERC-320441-Chir all carbonMinisterio de Economía y Competitividad CTQ2014-52045-R, CTQ2014-52328-PComunidad Autónoma de Madrid S2013/MIT-28