Suppression of COX-2, IL-1β and TNF-α expression and leukocyte infiltration in inflamed skin by bioactive compounds from Rosmarinus officinalis L.
- Mengoni, Eleonora Soledad
- Vichera, Gabriel Damian
- Rigano, Luciano Ariel
- Rodriguez Puebla, Marcelo L.
- Galliano, Silvia R.
- Cafferata, Eduardo E.
- Pivetta, Omar Hilario
- Moreno, Silvia
- Vojnov, Adrian Alberto
DOIAbstract
In the present study, we evaluated the effects of extracts and purified compounds from fresh leaves of Rosmarinus officinalis L. Pretreatment with the major anti-inflammatory compounds, carnosic acid (CA) and carnosol (CS), inhibited phorbol 12-myristate 13-acetate (PMA)-induced ear inflammation in mice with an EC(50) of 10.20 μg/cm(2) and 10.70 μg/cm(2), respectively. To further understand the anti-inflammatory mechanism of these compounds, we analyzed the in vivo expression of several inflammation-associated genes in mouse skin by reverse transcriptase-polymerase chain reaction (RT-PCR). Our data showed that CA and CS reduced the expression of IL-1β and TNF-α but had less effect on fibronectin and ICAM-1 expression. Interestingly, both co...
Add to ORKG