Thermosensitive nanogels based in dendritic polyglycerol and NIPAm for biomedical applications

In this paper we describe a methodology for the synthesis of thermoresponsive polyglycerol-based nanogels through precipitation polymerization. A systematic analysis of the preparative conditions and composition regarding the nanogel size is presented. The thermoresponsive properties of the synthesized nanogels, as well as the cytotoxicity and uptake in three different cell lines were investigated. The thermoresponsive behavior, the enhanced biocompatible profile, and the cell penetrating properties of the nanogels highlight the potential of such constructs for application as smart, environmentally-responsive materials.Fil: Cuggino, Julio César. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); ArgentinaFil: Alvarez Igarzabal, Cecilia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); ArgentinaFil: Strumia, Miriam Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); ArgentinaFil: Welker, Pia. mivenion GmbH; AlemaniaFil: Licha, Kai. mivenion GmbH; AlemaniaFil: Steinhilber, Dirk. Freie Universität Berlin; AlemaniaFil: Mutihac, Radu Cristian. Freie Universität Berlin; AlemaniaFil: Calderón, Marcelo. Freie Universität Berlin; Argentin