Altered microRNA expression levels in mononuclear cells of patients with pulmonary and pleural tuberculosis and their relation with components of the immune response
- Spinelli, Silvana Virginia
- Díaz, Ariana
- D'attilio, Luciano David
- Marchesini, Marcela M.
- Bogue, Cristina
- Bay, Maria Luisa
- Bottasso, Oscar Adelmo
DOIAbstract
Different lines of evidence demonstrate that microRNAs (miRNAs) play an important role in host–pathogen interactions. In this study we investigated the expression patterns of several miRNAs, most of them involved in regulating inflammatory responses, in patients with tuberculosis (TB). In order to understand the events occurring at the site of infection, we employed mononuclear cells obtained from both peripheral blood (PBMC) and pleural fluids (PFMC) of patients. Interestingly, we found that the miRNA signature of each compartment is different, with a strong down-regulation in PFMCs of miR-223, miR-144* and miR-421. In addition, we observed that miR-146a expression is also down-regulated in tuberculosis patients, both in PBMCs and PFMCs wh...
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