Dehydroepiandrosterone and metyrapone partially restore the adaptive humoral and cellular immune response in endotoxin immunosuppressed mice
- Rearte, Barbara
- Maglioco, Andrea Florencia
- Machuca, Damián Gabriel
- Martire Greco, Daiana
- Landoni, Verónica Inés
- Rodriguez Rodrigues, Nahuel Emiliano
- Meissl, Roberto Jose
- Fernández, Gabriela Cristina
- Isturiz, Martín Amadeo
DOIAbstract
Prior exposure to endotoxins renders the host temporarily refractory to subsequent endotoxin challenge (endotoxin tolerance). Clinically, this state has also been pointed out as the initial cause of the non-specific humoral and cellular immunosuppression described in these patients. We recently demonstrated the restoration of immune response with mifepristone (RU486), a receptor antagonist of glucocorticoids. Here we report the treatment with other modulators of glucocorticoids, i.e. dehydroepiandrosterone (DHEA), a hormone with anti-glucocorticoid properties, or metyrapone (MET) an inhibitor of corticosterone synthesis. These drugs were able to partially, but significantly, restore the humoral immune response in immunosuppressed mice. A si...
Add to ORKG