Deranged sodium to sudden death

In February 2014, a group of scientists convened as part of the University of California Davis Cardiovascular Symposium to bring together experimental and mathematical modelling perspectives and discuss points of consensus and controversy on the topic of sodium in the heart. This paper summarizes the topics of presentation and discussion from the symposium, with a focus on the role of aberrant sodium channels and abnormal sodium homeostasis in cardiac arrhythmias and pharmacotherapy from the subcellular scale to the whole heart. Two following papers focus on Na+ channel structure, function and regulation, and Na+/Ca2+ exchange and Na+/K+ ATPase. The UC Davis Cardiovascular Symposium is a biannual event that aims to bring together leading experts in subfields of cardiovascular biomedicine to focus on topics of importance to the field. The focus on Na+ in the 2014 symposium stemmed from the multitude of recent studies that point to the importance of maintaining Na+ homeostasis in the heart, as disruption of homeostatic processes are increasingly identified in cardiac disease states. Understanding how disruption in cardiac Na+-based processes leads to derangement in multiple cardiac components at the level of the cell and to then connect these perturbations to emergent behaviour in the heart to cause disease is a critical area of research. The ubiquity of disruption of Na+ channels and Na+ homeostasis in cardiac disorders of excitability and mechanics emphasizes the importance of a fundamental understanding of the associated mechanisms and disease processes to ultimately reveal new targets for human therapy.Fil: Clancy, Colleen E.. University Of California At Davis; Estados UnidosFil: Chen Izu, Ye. University Of California At Davis; Estados UnidosFil: Bers, Donald M.. University Of California At Davis; Estados UnidosFil: Belardinelli, Luiz. Gilead Sciences; Estados UnidosFil: Boyden, Penelope A.. Columbia University; Estados UnidosFil: Csernoch, Laszlo. University of Debrecen; HungríaFil: Despa, Sanda. University Of Kentucky; Estados UnidosFil: Fermini, Bernard. Pfizer; Estados UnidosFil: Hool, Livia C.. University of Western Australia; AustraliaFil: Izu, Leighton. University Of California At Davis; Estados UnidosFil: Kaas, Robert S.. Columbia University; Estados UnidosFil: Lederer, W. Jonathan. University of Maryland; Estados UnidosFil: Louch, William E.. University Of Oslo; NoruegaFil: Maack, Christoph. Universitat Saarland; AlemaniaFil: Mattiazzi, Ramona Alicia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico la Plata. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani"; Argentina. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; ArgentinaFil: Qu, Zhilin. University of California at Los Angeles; Estados UnidosFil: Rajamani, Sridharan. Gilead Sciences; Estados UnidosFil: Rippinger, Crystal M.. University Of California At Davis; Estados UnidosFil: Sejersted, Ole M.. University Of Oslo; NoruegaFil: O’Rourke, Brian. University Johns Hopkins; Estados UnidosFil: Weiss, James N.. University of California at Los Angeles; Estados UnidosFil: Varró, András. University of Szeged; HungríaFil: Zaza, Antonio. Universita Degli Studi Di Milano; Itali