Alterations of locomotor activity rhythm and sleep parameters in patients with advanced glaucoma
- Lanzani, María Florencia
- de Zavalia, Nuria Maria Asuncion
- Fontana, Héctor
- Keller Sarmiento, Maria Ines
- Golombek, Diego Andres
- Rosenstein, Ruth Estela
DOIAbstract
The aim of this study was to evaluate the effect of advanced glaucoma on locomotor activity rhythms and related sleep parameters. Nine normal subjects and nine age-matched patients with bilateral advanced primary open-angle glaucoma, >10 yrs since diagnosis, were included in this observational, prospective, case-control study. Patients were required to record the timing and duration of their sleep and daily activities, and wore an actigraph on the wrist of the nondominant arm for 20 d. Activity rhythm period, MESOR (24-h time-series mean), amplitude (one-half peak-to-trough variation), and acrophase (peak time), plus long sleep episodes during the wake state, sleep duration, efficiency, and latency, as well as mean activity score, wake minu...
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