Identification of a novel Pfkfb1 mRNA variant in rat fetal liver
- Cosin Roge, Jesús
- Vernia, Santiago
- Alvarez, María Soledad
- Cucarella, Carme
- Boscá, Lisardo
- Martin Sanz, Paloma
- Fernández Alvarez, Ana Julia
- Casado, Marta
DOIAbstract
The bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase-2) catalyzes the synthesis and degradation of fructose-2,6-bisphosphate, a key metabolite in the glucose homeostasis. Four genes, Pfkfb1-4, have been characterized in mammals that code for several isoforms generated by alternative splicing through the control of several promoters and 5' non-coding exons. Here, we characterize in fetal rat liver new mRNA variants which are transcribed from a new Pfkfb1 gene promoter. The long variant codes to a new isoform (FL-PFK-2) that would be of relevant function to modulate the transition of fetal to adult liver metabolism.Fil: Cosin Roge, Jesús. Consejo Superior de Investigaciones Cientificas; EspañaFil: Vernia,...