Inhibitory role of ERβ on anterior pituitary cell proliferation by controlling the expression of proteins related to cell cycle progression
- Pérez, Pablo Aníbal
- Petiti, Juan Pablo
- Wagner, Ignacio A.
- Sabatino, María Eugenia
- Sasso, Corina Verónica
- de Paul, Ana Lucia
- Torres, Alicia Ines
- Gutiérrez, Silvina
DOIAbstract
Considering that the role of ERβ in the growth of pituitary cells is not well known, the aim of this work was to determine the expression of ERβ in normal and tumoral cells and to investigate its implications in the proliferative control of this endocrine gland, by analyzing the participation of cyclin D1, Cdk4 and p21. Our results showed that the expression of ERβ decreased during pituitary tumoral development induced by chronic E2 stimulation. The 20 ± 1.6% of normal adenohypophyseal cells expressed ERβ, with this protein being reduced in the hyperplastic/adenomatous pituitary: at 20 days the ERβ+ population was 10.7 ± 2.2%, while after 40 and 60 days of treatment an almost complete loss in the ERβ expression was observed (40d: 1 ± 0.6%; ...
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