Dehydration affects cardiovascular nitric oxide synthases and caveolins in growing rats
- Netti, Vanina Alejandra
- Iovane, Agustina N.
- Vatrella, Mariana C.
- Magnani, Natalia Daniela
- Evelson, Pablo Andres
- Zotta, Elsa
- Fellet, Andrea L.
- Balaszczuk, Ana Maria
DOIAbstract
PURPOSE: During the postnatal stage, cardiovascular nitric oxide (NO) system and caveolins (cav) may be regulated differentially in response to hypovolemic state induced by water restriction. Our aim was to examine the effects of water restriction on NO synthases (NOS) and cav in the atria, ventricle and aorta of growing rats. METHODS: Male Sprague-Dawley rats aged 25 and 50 days were divided into (n = 15): WR: water restriction 3 days; WAL: water ad libitum 3 days. Systolic blood pressure, NOS activity and NOS/cav protein levels were measured. RESULTS: Dehydration induced a larger increase in SBP in WR25 group. Ventricular NOS activity, endothelial NOS (eNOS) and neuronal isoform (nNOS) of WR25 pups were increased, and both cav were decrea...
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