Consequences of presentation with advanced HIV disease in pregnancy: Data from a national study in Italy
- Floridia, M
- Tamburrini, E
- Masuelli, G
- Guaraldi, G
- Molinari, A
- Cetin, I
- Dalzero, S
- Spinillo, A
- Liuzzi, G
- Pinnetti, C
- Vicini, I
- Castelli, P
- Sacchi, V
- Ravizza, M
Publication date
January 2015
DOI Publisher
Ovid Technologies (Wolters Kluwer Health)Abstract
Among 469 women with a diagnosis of HIV in pregnancy, 74 (15.8%) presented with less than 200 CD4 cells per cubic millimeter. The only variable significantly associated with this occurrence was African origin (odds ratio: 2.22, 95% confidence intervals: 1.32 to 3.75, P = 0.003). Four women with low CD4 (5.6%), compared with none with higher CD4 counts, had severe AIDS-defining conditions (P < 0.001) during pregnancy or soon after delivery, and one transmitted HIV to the newborn. Early preterm delivery (<32 weeks) was significantly more frequent with low CD4 (6.2% vs. 1.4%, P = 0.015). An earlier access to HIV testing, particularly among immigrants of African origin, can prevent severe HIV-related morbidity
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