Striatal dopamine depletion is a key pathophysiological feature of Parkinson's disease (PD) causing motor and nonmotor symptoms. Research on nonmotor symptoms has mainly focused on frontostriatal functions. However, dopamine pathways ascending from the ventral tegmental area also innervate hippocampal structures and modulate hippocampal-dependent functions, such as spatial memory. Using a virtual spatial navigation task, we investigated dopaminergic modulation of spatial memory in PD patients in a crossover medication ON/OFF design. We examined medication effects on striatal- and hippocampal-dependent spatial memory by either replacing a location cue in the environment or enlarging its spatial boundary. Key results indicate that in contrast...
Reduced levels of dopamine in Parkinson's disease contribute to changes in learning, resulting from ...
Emerging evidence suggests that dopamine may modulate learning and memory with important implication...
Visual-spatial working memory (WM) impairment is frequently associated with the early stage of Parki...
Striatal dopamine depletion is a key pathophysiological feature of Parkinson's disease (PD) causing ...
RATIONALE: Accumulating evidence in humans demonstrated that visuo-spatial deficits are the most con...
Rationale Accumulating evidence in humans demonstrated that visuo-spatial deficits are the most cons...
Visuospatial working memory (WM) impairments in Parkinson's disease (PD) are more prominent and evol...
Dysfunctions in dopaminergic neurotransmission lead to motor symptoms and cognitive impairments asso...
Increasingly memory deficits are recognized in Parkinson's disease (PD). In PD, the dopamine-produci...
<div><p>Increasingly memory deficits are recognized in Parkinson's disease (PD). In PD, the dopamine...
Item does not contain fulltextDopaminergic medication in Parkinsons disease has been proposed to imp...
We investigated the hypothesis that variation in endogenous dopamine (DA) across brain regions expla...
Parkinson's disease (PD) patients show cognitive deficits that are relevant in terms of prognosis an...
Parkinson's disease (PD) patients exhibit cognitive deficits, including reinforcement learning, work...
Dopamine appears to play a critical role in regulating spatial working memory (SWM) in non-human pri...
Reduced levels of dopamine in Parkinson's disease contribute to changes in learning, resulting from ...
Emerging evidence suggests that dopamine may modulate learning and memory with important implication...
Visual-spatial working memory (WM) impairment is frequently associated with the early stage of Parki...
Striatal dopamine depletion is a key pathophysiological feature of Parkinson's disease (PD) causing ...
RATIONALE: Accumulating evidence in humans demonstrated that visuo-spatial deficits are the most con...
Rationale Accumulating evidence in humans demonstrated that visuo-spatial deficits are the most cons...
Visuospatial working memory (WM) impairments in Parkinson's disease (PD) are more prominent and evol...
Dysfunctions in dopaminergic neurotransmission lead to motor symptoms and cognitive impairments asso...
Increasingly memory deficits are recognized in Parkinson's disease (PD). In PD, the dopamine-produci...
<div><p>Increasingly memory deficits are recognized in Parkinson's disease (PD). In PD, the dopamine...
Item does not contain fulltextDopaminergic medication in Parkinsons disease has been proposed to imp...
We investigated the hypothesis that variation in endogenous dopamine (DA) across brain regions expla...
Parkinson's disease (PD) patients show cognitive deficits that are relevant in terms of prognosis an...
Parkinson's disease (PD) patients exhibit cognitive deficits, including reinforcement learning, work...
Dopamine appears to play a critical role in regulating spatial working memory (SWM) in non-human pri...
Reduced levels of dopamine in Parkinson's disease contribute to changes in learning, resulting from ...
Emerging evidence suggests that dopamine may modulate learning and memory with important implication...
Visual-spatial working memory (WM) impairment is frequently associated with the early stage of Parki...