Add to ORKGKetamine is a potent glutamatergic NMDA receptor antagonist with rapid antidepressant properties at subanaesthetic doses, thus providing a valuable research tool for the investigation of the neurobiology of major depressive disorder (MDD). This double-blind, randomized, placebo-controlled 1H-MRS study in 13 healthy subjects reveals the neuropharmacological effects of a single intravenous subanaesthetic ketamine infusion on prefrontal aspartate, glutamine and GABA levels in the 3-4 hour post-infusion interval. Our findings are in line with a shift in the excitatory-inhibitory balance following ketamine administration that may play an important role in restoring parts of the disrupted neurometabolic homeostasis in MDD patients
Increased amygdala reactivity might lead to negative bias during emotional processing that can be re...
Many neuroimaging findings are compatible with the hypothesis that limbic hyperactivity during evalu...
Background Identifying the neural correlates of ketamine treatment may facilitate and expedite the d...
Ketamine is a potent glutamatergic NMDA receptor antagonist with rapid antidepressant properties at ...
Background: Using proton magnetic resonance spectroscopy (1H-MRS) an increase in glutamatergic metab...
Objective Using proton magnetic resonance spectroscopy (1H-MRS) an increase in glutamatergic metabol...
Background: Ketamine is a potent NMDA receptor antagonist with rapid antidepressant properties at su...
Ketamine is a potent glutamatergic NMDA receptor antagonist with rapid antidepressant properties at ...
Introduction: Increasing preclinical and clinical evidence underscores the role of glutamate in the ...
Background / Purpose: Ketamine is a potent glutamatergic NMDA receptor antagonist with rapid antidep...
Ketamine is a potent glutamatergic NMDA receptor antagonist with rapid antidepressant properties, th...
Introduction: Converging evidence suggests that ketamine elicits antidepressant effects via enhance...
Introduction Subanesthetic dose of ketamine was repeatedly shown to improve depressive symptoms with...
Ketamine is a powerful glutamatergic long-lasting antidepressant, efficient in intractable major dep...
Conventional antidepressants acting through serotonin and/or noradrenaline fail to help about half o...
Increased amygdala reactivity might lead to negative bias during emotional processing that can be re...
Many neuroimaging findings are compatible with the hypothesis that limbic hyperactivity during evalu...
Background Identifying the neural correlates of ketamine treatment may facilitate and expedite the d...
Ketamine is a potent glutamatergic NMDA receptor antagonist with rapid antidepressant properties at ...
Background: Using proton magnetic resonance spectroscopy (1H-MRS) an increase in glutamatergic metab...
Objective Using proton magnetic resonance spectroscopy (1H-MRS) an increase in glutamatergic metabol...
Background: Ketamine is a potent NMDA receptor antagonist with rapid antidepressant properties at su...
Ketamine is a potent glutamatergic NMDA receptor antagonist with rapid antidepressant properties at ...
Introduction: Increasing preclinical and clinical evidence underscores the role of glutamate in the ...
Background / Purpose: Ketamine is a potent glutamatergic NMDA receptor antagonist with rapid antidep...
Ketamine is a potent glutamatergic NMDA receptor antagonist with rapid antidepressant properties, th...
Introduction: Converging evidence suggests that ketamine elicits antidepressant effects via enhance...
Introduction Subanesthetic dose of ketamine was repeatedly shown to improve depressive symptoms with...
Ketamine is a powerful glutamatergic long-lasting antidepressant, efficient in intractable major dep...
Conventional antidepressants acting through serotonin and/or noradrenaline fail to help about half o...
Increased amygdala reactivity might lead to negative bias during emotional processing that can be re...
Many neuroimaging findings are compatible with the hypothesis that limbic hyperactivity during evalu...
Background Identifying the neural correlates of ketamine treatment may facilitate and expedite the d...