A rectangular layout is a partition of a rectangle into a finite set of interior-disjoint rectangles. These layouts are used as rectangular cartograms in cartography, as floorplans in building architecture and VLSI design, and as graph drawings. Often areas are associated with the rectangles of a rectangular layout and it is desirable for one rectangular layout to represent several area assignments. A layout is area-universal if any assignment of areas to rectangles can be realized by a combinatorially equivalent rectangular layout. We identify a simple necessary and sufficient condition for a rectangular layout to be area-universal: a rectangular layout is area-universal if and only if it is one-sided. We also investigate similar questions...