Based on fieldwork and literature review we have investigated the rise and fall of jatropha cultivation in Tanzania over the last decade, and its negative socio-economic and environmental impacts. Based on the fact that the most vulnerable actors, small farmers, were affected the most, through loss of land and income, we conclude that biofuel innovations have so far been irresponsible. In this chapter we draw lessons for future biofuel innovations through the identification of stakeholder responsibilities. We do so by developing a framework which is based on current discussions on the meaning of ‘sustainability’ and recent ethical work on moral responsibility. In addition, we use the framework to reflect on the jatropha biofuel innovation e...