A Large Scale Printer (LSP) is a Cyber Physical System (CPS) printing thousands of sheets per day with high quality. The print requests arrive at run-time requiring online scheduling. We capture the LSP scheduling problem as online scheduling of re-entrant flowshops with sequence dependent setup times and relative due dates with makespan minimization as the scheduling criterion. Exhaustive approaches like Mixed Integer Programming can be used, but they are compute intensive and not suited for online use. We present a novel heuristic for scheduling of LSPs that on average requires 0.3 seconds per sheet to find schedules for industrial test cases. We compare the schedules to lower bounds, to schedules generated by the current scheduler and sc...