A rectangular layout is a partition of a rectangle into a finite set of interior-disjoint rectangles. Rectangular layouts appear in various applications: as rectangular cartograms in cartography, as floorplans in building architecture and VLSI design, and as graph drawings. Often areas are associated with the rectangles of a rectangular layout and it might hence be desirable if one rectangular layout can represent several area assignments. A layout is area-universal if any assignment of areas to rectangles can be realized by a combinatorially equivalent rectangular layout. We identify a simple necessary and sufficient condition for a rectangular layout to be area-universal: a rectangular layout is area-universal if and only if it is one-sid...