103. Reward Sensitivity and \u201cunbalance\u201d cortical effect as a biomarker of new addictions. A multi-method study

The present study explored the effect of cortical lateralisation activity during the decisional process in a gambling context. It is assumed that increasing of the left DLPFC activity and personality trait make subjects\u2019 strategies more disadvantageous and \u201cgambling\u201d during an online game. Twenty-one subjects were tested using the IGT and GO/noGo task while the EEG was registered and alpha-band modulation was considered. Secondly, the Behavioral Activation System (BAS)/Behavioral Inhibition System (BIS) scale was used to test the effect of reward sensitivity. Moreover, metacognitive questionnaire was applied. It was found that high-BAS subjects increased their tendency to opt in favour of the immediate reward rather than the long-term option, while a significant increasing of the left-hemisphere activation was found in response to immediate reward choices compared to low-BAS subjects. Finally, they tended to have difficulties to inhibit the automatic response, and they showed dysfunction of metacognitive abilities. A reward bias effect was supposed to explain both the bad strategy and the unbalanced hemispheric activation for high-BAS subjects. These findings could have important repercussions in the social context for the prevention of dysfunctional behaviours that affect compulsive disorders like new forms of addiction