Specific members of the predominant gut microbiota predict pouchitis following colectomy and IPAA in UC
- Machiels, K.
- Sabino, J.
- Vandermosten, L.
- Joossens, M.
- Arijs, I.
- de Bruyn, M.
- Eeckhaut, V.
- Van Assche, G.
- Ferrante, M.
- Verhaegen, J.
- Van Steen, Kristel
- Van Immerseel, F.
- Huys, G.
- Verbeke, K.
- Wolthuis, A.
- de Buck Van Overstraeten, A.
- D'Hoore, A.
- Rutgeerts, P.
- Vermeire, S.
DOIAbstract
OBJECTIVE: Pouchitis is the most common complication after colectomy with ileal pouch-anal anastomosis (IPAA) for UC and the risk is the highest within the 1st year after surgery. The pathogenesis is not completely understood but clinical response to antibiotics suggests a role for gut microbiota. We hypothesised that the risk for pouchitis can be predicted based on the faecal microbial composition before colectomy.DESIGN: Faecal samples from 21 patients with UC undergoing IPAA were prospectively collected before colectomy and at predefined clinical visits at 1 month, 3 months, 6 months and 12 months after IPAA. The predominant microbiota was analysed using community profiling with denaturing gradient gel electrophoresis followed by quantit...
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