Cluster analysis of hormonal constellation at women and men with harmonious and disharmonious general adaptation reactions

Hrytsak Yaroslav L, Barylyak Liliya G, Zukow Walery, Popovych Igor L. Cluster analysis of hormonal constellation at women and men with harmonious and disharmonious general adaptation reactions. Journal of Education, Health and Sport. 2016;6(4):141-150. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.49942 http://ojs.ukw.edu.pl/index.php/johs/article/view/3461 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015). 755 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Author (s) 2016; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 20.03.2016. Revised 17.04.2016. Accepted: 17.04.2016. CLUSTER ANALYSIS OF HORMONAL CONSTELLATION AT WOMEN AND MEN WITH HARMONIOUS AND DISHARMONIOUS GENERAL ADAPTATION REACTIONS Yaroslav L Hrytsak1, Liliya G Barylyak1,2,3, Walery Zukow4, Igor L Popovych3 1Hotel Spa Complex “Karpaty”, Truskavets’, Ukraine hrytsak.y@gmail.com 2JSC “Truskavets’kurort”, Truskavets’, Ukraine lgbarylyak@biph.kiev.ua 3Laboratory of Experimental Balneology, OO Bogomoletz Institute of Physiology NAS, Truskavets’-Kyiv, Ukraine i.popovych@biph.kiev.ua 4Faculty of Physical Education, Health and Tourism, Kazimierz Wielki University, Bydgoszcz, Poland w.zukow@ukw.edu.pl Abstracts Background. It is known that the nervous, endocrine and immune systems interact closely with each other to form a three-pronged neuro-endocrine-immune complex. On of manifest of causal neuroendocrine-immune relationships is Leukocytogram of peripheral blood that differ by various constellation of Principal Adaptation Hormones. Material and research methods. We determined twice at ten women and ten men aged 33-76 years without clinical diagnose serum levels of Cortisol, Aldosterone, Triiodothyronine, Testosterone and Calcitonin (ELISA) as well as Popovych’s Adaptation Index by Leukocytogram. Results. All case was distributed among four clusters. Cluster N1 contains 5 cases with drastically hypercortisolemia and moderately hypercalcitoninemia; 5 other cases characterized moderately hypercortisolemia and borderline level of Triiodothyronine, together reflected chronic stress. Majority of cases (Cluster N3) characterized upper borderline level of Cortisol and normal levels others hormones, while in 5 cases (Cluster N4) hormonal costellation is also normal but with lower borderline level of Cortisol. Estimation by Leukocytogram Popovych’s Adaptation Index shown that at 25 cases take place Harmonious General Adaptation Reactions (GAR) as markers of health while at 15 cases detected Disharmonious GAR as markers of premorbidic stage. Conclusion. Constellations of principal Adaptation Hormones displays widely variability representing different gradations of health and premobide states. Calcitonin may be considered as one of principal Adaptation Hormones. Keywords: Cortisol, Aldosterone, Triiodothyronine, Testosterone, Calcitonin, General Adaptation Reactions