THE EFFECT OF VITAMIN E SUPPLEMENTATION ON LIPID PROFILE AND OXIDATIVE STRESS MARKERS IN HEMODIALYSIS PATIENTS

<p class="abstract"><strong>Abstract</strong></p> <p class="abstract"><strong>INTRODUCTION: </strong>Dyslipidemia and oxidative stress are thought to be important mechanisms in pathogenesis of disease in hemodialysis patients. This study was designed to investigate the efficacy of oral vitamin E supplementation on lipid profile and oxidative stress in hemodialysis patients.</p> <p class="abstract"><strong>METHODS: </strong>The study group consisted of 26 uremic patients (10 women and 16 men), 16-68 years of age undergoing maintenance hemodialysis three times a week (12&nbsp;hours/week), lasting a range of 6-108 months, at Vali-e-Asre Hospital in Birjand (Iran). Total Antioxidant Capacity (TAC), lipid peroxidation, cholesterol, triglyceride, high-density lipoprotein and low-density lipoprotein levels were determined before and after oral vitamin E supplementation, 400&nbsp;mg/d for 90 days.</p> <p class="abstract"><strong>RESULTS:</strong> Vitamin E supplementation caused a significant decrease in ThioBarbituric Acid Reactive Substances (TBARS) level as a marker for lipid peroxidation (2.97&plusmn;0.52 vs. 2.55&plusmn;0.44, P&lt;0.001) and a significant increase in plasma TAC (1252&plusmn;348 vs. 1398&plusmn;372, P&lt;0.01). Although there was a decrease in the level of lipid profile, there were no statistically significant differences in the means of cholesterol, triglyceride, high-density lipoprotein and low-density lipoprotein before and after vitamin E supplementation among patients.</p> <p class="abstract"><strong>CONCLUSION:</strong> Our results indicated that oral vitamin E supplementation might be able to modify oxidative stress by an increase in TAC, and a decrease in lipid peroxidation; that could be considered as a preventive strategy in hemodialysis patients</p> <p class="abstract">&nbsp;</p><table cellspacing="0" cellpadding="0" align="left"><tbody><tr><td width="35" height="12">&nbsp;</td></tr> <tr><td>&nbsp;</td> <td>&nbsp;</td></tr></tbody></table><p class="abstract">&nbsp;</p> <br /> <p class="abstract"><strong>Keywords:</strong> Antioxidant capacity, lipid peroxidation, lipid profile, vitamin E, hemodialysis.</p> <p class="abstract">&nbsp;