Excessive generation of reactive oxygen species (ROS) in mitochondria and the opening of the nonselective mitochondrial permeability transition pore are important factors that promote cardiac pathologies and dysfunction. The hormone melatonin (MEL) is known to improve the functional state of mitochondria via an antioxidant effect. Here, the effect of MEL administration on heart mitochondria from aged rats with acute cardiac failure caused by isoprenaline hydrochloride (ISO) was studied. A histological analysis revealed that chronic intake of MEL diminished the age-dependent changes in the structure of muscle fibers of the left ventricle, muscle fiber swelling, and injury zones characteristic of acute cardiac failure caused by ISO. In acute ...
To investigate the role of NLRP3 inflammasome in cardiac aging, we evaluate here morphological and u...
Considering the cardioprotective and antioxidant properties of melatonin, in the present experiment,...
Abstract. The effect of melatonin on reperfusion arrhythmias and postischemic contractile dysfunctio...
Excessive generation of reactive oxygen species (ROS) in mitochondria and the opening of the nonsele...
To explore the combined effects of exercise and melatonin supplement against the challenges of isopr...
Melatonin, a well-known antioxidant, has been shown to protect against ischemia-reperfusion m...
Cardiomyocytes are particularly sensitive to oxidative damage due to the link between mitochondria a...
Cardiomyocytes are particularly sensitive to oxidative damage due to the link between mitochondria a...
The objective of this study was to examine the in vivo effect of melatonin on rat mitochondrial live...
Aging is a major risk for cardiovascular diseases (CVD). Age-related disorders include oxidative str...
Abstract: Mitochondrial dysfunction is considered one of the major causative factors in the aging pr...
Aging comes with gradual loss of functions that increase the vulnerability to disease, senescence, a...
The present study was designed to evaluate the cardioprotective effects of melatonin (a single dose ...
Oxidative stress-induced mitochondrial dysfunction plays a crucial role in the pathogenesis of a wid...
To understand the mechanism of cardiovascular dysfunction in the hyperthyroid condition, the role of...
To investigate the role of NLRP3 inflammasome in cardiac aging, we evaluate here morphological and u...
Considering the cardioprotective and antioxidant properties of melatonin, in the present experiment,...
Abstract. The effect of melatonin on reperfusion arrhythmias and postischemic contractile dysfunctio...
Excessive generation of reactive oxygen species (ROS) in mitochondria and the opening of the nonsele...
To explore the combined effects of exercise and melatonin supplement against the challenges of isopr...
Melatonin, a well-known antioxidant, has been shown to protect against ischemia-reperfusion m...
Cardiomyocytes are particularly sensitive to oxidative damage due to the link between mitochondria a...
Cardiomyocytes are particularly sensitive to oxidative damage due to the link between mitochondria a...
The objective of this study was to examine the in vivo effect of melatonin on rat mitochondrial live...
Aging is a major risk for cardiovascular diseases (CVD). Age-related disorders include oxidative str...
Abstract: Mitochondrial dysfunction is considered one of the major causative factors in the aging pr...
Aging comes with gradual loss of functions that increase the vulnerability to disease, senescence, a...
The present study was designed to evaluate the cardioprotective effects of melatonin (a single dose ...
Oxidative stress-induced mitochondrial dysfunction plays a crucial role in the pathogenesis of a wid...
To understand the mechanism of cardiovascular dysfunction in the hyperthyroid condition, the role of...
To investigate the role of NLRP3 inflammasome in cardiac aging, we evaluate here morphological and u...
Considering the cardioprotective and antioxidant properties of melatonin, in the present experiment,...
Abstract. The effect of melatonin on reperfusion arrhythmias and postischemic contractile dysfunctio...