Mathematical methods for quantification and comparison of dissolution testing data

<span>In recent years, drug release/</span><span class="highlight">dissolution</span><span> from solid dosage forms has been the subject of intense and profitable scientific developments. Whenever a new solid dosage form is developed or produced, it is necessary to ensure that drug </span><span class="highlight">dissolution</span><span>occurs in an appropriate manner. The pharmaceutical industry and the registration authorities do focus, nowadays, on drug </span><span class="highlight">dissolution</span><span> studies. The quantitative analysis of the values obtained in </span><span class="highlight">dissolution</span><span>/release tests is easier when </span><span class="highlight">mathematical</span><span>formulas that express the </span><span class="highlight">dissolution</span><span> results as a function of some of the dosage forms characteristics are used. This work discusses the analysis of </span><span class="highlight">data</span><span> obtained for </span><span class="highlight">dissolution</span><span> profiles under different media pH conditions using </span><span class="highlight">mathematical</span><span> </span><span class="highlight">methods</span><span>of analysis described by Moore and Flanner. These authors have described difference factor (f1) and similarity factor (f2), which can be used to characterise drug </span><span class="highlight">dissolution</span><span>/release profiles. In this work we have used these formulas for evaluation of </span><span class="highlight">dissolution</span><span> profiles of the conventional tablets in different pH of </span><span class="highlight">dissolution</span><span> medium (range of physiological variations).