Fluoxetine (FLX) is one of the selective serotonin reuptake inhibitors (SSRIs) antidepressants, which could be used to relieve depression and anxiety among AD patients. This study was designed to search for new mechanisms by which fluoxetine could activate Wnt/β-catenin signaling pathway and reduce amyloidosis in AD brain. Fluoxetine was administered via intragastric injection to APP/tau/PS1 mouse model of Alzheimer’s disease (3×Tg-AD) mice for 4 months. In the hippocampus of AD mouse model, there could be observed neuronal apoptosis, as well as an increase in Aβ (amyloid-β) production. Moreover, there is a strong association between down-regulation of Wnt/β-catenin signaling and the alteration of AD pathology. The activity of protein phosp...
Indirect agonism has been invoked as part of the mechanism of antipsychotic action at dopamine D2/3 ...
Fluoxetine (FLX) represents the antidepressant of choice for the management of pediatric mood-relate...
Parkinson\u27s disease (PD) is characterized by degeneration of nigrostriatal dopaminergic (DA) neur...
Depression is a risk factor for the development of Alzheimer's disease (AD). A neurobiological and c...
Treatment of Alzheimer's disease (AD) patients with the antidepressant fluoxetine is known to improv...
Trabajo presentado al 38th Annual Meeting of American Society for Neuroscience celebrado en Washingt...
Depression is a risk factor for the development of Alzheimer's disease (AD), and the presence of dep...
<div><p>Abnormal activation of the Wnt/β-catenin signaling is implicated in the osteoarthritis (OA) ...
A selective serotonin reuptake inhibitor, fluoxetine, has recently attracted a significant interest ...
Reductions in adult neurogenesis have been documented in the original 3xTg mouse model of Alzheimer'...
Mucopolysaccharidosis type IIIA (MPS-IIIA) is an autosomal recessive disorder caused by mutations in...
Introduction: Axonal transport deficit is a key mechanism involved in neurodegenerative conditions. ...
Alzheimer's disease (AD) is a major and devastating neurodegenerative disease, and the amyloid-β (Aβ...
Individuals with Down syndrome (DS), a genetic condition caused by triplication of chromosome 21, ar...
Abstract Motor skill deficit is a common and invalidating symptom of Rett syndrome (RTT), a rare dis...
Indirect agonism has been invoked as part of the mechanism of antipsychotic action at dopamine D2/3 ...
Fluoxetine (FLX) represents the antidepressant of choice for the management of pediatric mood-relate...
Parkinson\u27s disease (PD) is characterized by degeneration of nigrostriatal dopaminergic (DA) neur...
Depression is a risk factor for the development of Alzheimer's disease (AD). A neurobiological and c...
Treatment of Alzheimer's disease (AD) patients with the antidepressant fluoxetine is known to improv...
Trabajo presentado al 38th Annual Meeting of American Society for Neuroscience celebrado en Washingt...
Depression is a risk factor for the development of Alzheimer's disease (AD), and the presence of dep...
<div><p>Abnormal activation of the Wnt/β-catenin signaling is implicated in the osteoarthritis (OA) ...
A selective serotonin reuptake inhibitor, fluoxetine, has recently attracted a significant interest ...
Reductions in adult neurogenesis have been documented in the original 3xTg mouse model of Alzheimer'...
Mucopolysaccharidosis type IIIA (MPS-IIIA) is an autosomal recessive disorder caused by mutations in...
Introduction: Axonal transport deficit is a key mechanism involved in neurodegenerative conditions. ...
Alzheimer's disease (AD) is a major and devastating neurodegenerative disease, and the amyloid-β (Aβ...
Individuals with Down syndrome (DS), a genetic condition caused by triplication of chromosome 21, ar...
Abstract Motor skill deficit is a common and invalidating symptom of Rett syndrome (RTT), a rare dis...
Indirect agonism has been invoked as part of the mechanism of antipsychotic action at dopamine D2/3 ...
Fluoxetine (FLX) represents the antidepressant of choice for the management of pediatric mood-relate...
Parkinson\u27s disease (PD) is characterized by degeneration of nigrostriatal dopaminergic (DA) neur...