Estimation of serological landscape of nazofaringeal strains of Streptococcus pneumoniae circulating in the territory of Barnaul

Aim. To study the prevalence of S. pneumoniae serotypes in nasopharyngeal carriage among different age groups in organized groups to optimize the information and analytical system of epidemiological surveillance of pneumococcal infection. Methods. By classical bacteriological method 75 nasopharyngeal isolates of pneumococcus, which later were serotyped, were identified in 319 subjects of different age from children's and adults' organized groups in Barnaul. Results. In 2017 the epidemiological screening was used to evaluate the prevalence of S. pneumoniae carriage. After identification, nasopharyngeal pneumococcal strains underwent serotyping. The greatest proportion of serological landscape of the studied strains was 3 and 19F serotypes, the total proportion of which was 75±9.7%. 13-valent pneumococcal conjugated vaccine had the maximum coverage of local strains - 62.5%. Based on the data on community-acquired pneumonia caused most often by pneumococcus, from information and analytical system received from the territories of the region, the database «Community-acquired pneumonia of the Altai Krai» was created. However, for an adequate assessment of the epidemiological situation regarding pneumococcal infection in the region, incoming information was not enough. The analysis of information from the territories on community-acquired pneumonia allowed identifying disadvantages of epidemiological surveillance of this nosology and inability to adequately assess the epidemiological situation with regard to pneumococcal infection in the region. Conclusion. The results of serotyping allowed determining further tactics of immunization in the Altai Krai; information and analytical system requires supplementing microbiological monitoring data regarding antibiotic susceptibility and resistance to disinfectants of the etiological agent