Chemopeventive Effects of Andographis Panniculata Extract in Vivo and in Vitro Models

An Andrographis panniculata leaf extract was used against 7, 12 - dimethylbenz (a) anthracene (DMBA) induced papillomagenesis in Swiss albino mice was studied. Andrographis panniculata methanolic extracts were analyzed for Chemopreventive activity. Chemopreventive activity was evaluated using a two stage protocol consisting of initiation with a single topical application of a carcinogen (7, 12 - dimethylbenz (a) anthracene (DMBA) followed by a promoter (croton oil) twice a week. Tumor incidence, tumor burden and papillomas numbers reduction were observed, along with an increase in the average latent period for in mice treated topically with Andrographis panniculata extract compared to the control group treated with DMBA and croton oil alone. Andrographis panniculata antibacterial and antioxidant activities were also observed in the in vitro model revealing information about the anticancer, antibacterial and antioxidant activities of an Andrographis panniculata extract