Study of population frequencies of genes polymorphism associated with preeclampsia-associated genes polymorphism

Using high-density microarrays, we analyzed polymorphism of more than 1500 genetic markers associated with risk of a wide range of multifactorial diseases. Based on functional annotation of genes by bioinformatics resources DAVID and GFINDer we selected a group of 31 genes, whose products are associated with the risk of preeclampsia. Population frequencies of alleles and genotypes for the following genes: ACE, ADIPOQ, ADRB2, ADRB3, AGT, APOE, CRP, CTLA4, CYP1A1, CYP2D6, CYP2E1, EDNRA, ESR1, ESR2, F5, HLA-DQA1, HSPA1A, IL1A, IL1RN, IL6, IL6R, LEP, LEPR, LPL, MTHFR, NOS3, PON1, TAP2, TGFB1, TNFA, VEGFA were established. Comparative analysis between the Russian and Central European population groups revealed statistically significant differences in allele and genotype frequencies for 6 genes: CYP2D6, CTLA4, AGT, NOS3, PON1, ADRB2. The data suggest similar basis of genetic risk of vascular diseases in pregnancy in Russian and European populations and may be used for other genetic and epidemiological studie