Arrhythmogenic Cardiomyopathy: Genetic Pathology, Inflammatory Syndrome, or both?

Héctor O. Rodríguez

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Publication date

October 2017

Publisher

European Medical Journal

Journal

issn:2054-3174

Abstract

Arrhythmogenic cardiomyopathy (ACM) affects mainly young athletes <35 years old and has a potential risk of malignant arrhythmias and sudden death. Different post-mortem and clinical studies have been conducted in North America, Asia, and Europe, with sharp differences in incidence and sex-associated pattern. Alterations in desmosome proteins, such as desmoglein, plakophilin, ion channels, or intracellular calcium handling proteins, have been highlighted as the principal cause of ACM, but the pathology has shown more complexity than initially described. This short review summarises the principal and more recent findings about ACM, mainly those related to inflammatory phenomena reported in the literature. Viral infections, especially enterov...

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Arrhythmogenic Cardiomyopathy: Genetic Pathology, Inflammatory Syndrome, or both?

Abstract

Extracted data

Arrhythmogenic Cardiomyopathy: Genetic Pathology, Inflammatory Syndrome, or both?

Abstract

Extracted data

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