Buruli ulcer (BU), the third most frequent mycobacteriosis worldwide, is a neglected tropical disease caused by Mycobacterium ulcerans. We report the clinical description and extensive genetic analysis of a consanguineous family from Benin comprising two cases of unusually severe non-ulcerative BU. The index case was the most severe of over 2,000 BU cases treated at the Centre de Dépistage et de Traitement de la Lèpre et de l'Ulcère de Buruli, Pobe, Benin, since its opening in 2003. The infection spread to all limbs with PCR-confirmed skin, bone and joint infections. Genome-wide linkage analysis of seven family members was performed and whole-exome sequencing of both patients was obtained. A 37 kilobases homozygous deletion confirmed by tar...
Mycobacterium ulcerans is the causative agent of Buruli ulcer, the third most common mycobacterial d...
<div><p>Background</p><p><i>Mycobacterium ulcerans</i> is the causative agent of the necrotizing ski...
Buruli ulcer is an emerging and neglected tropical disease caused byMycobacterium ulcer-ans. Few cas...
International audienceBuruli ulcer (BU), the third most frequent mycobacteriosis worldwide, is a neg...
Buruli Ulcer (BU), caused by Mycobacterium ulcerans, is the third most common mycobacteriosis worldw...
International audienceBuruli ulcer, caused by Mycobacterium ulcerans and characterized by devastatin...
Buruli ulcer (BU) is an emerging necrotizing disease of the skin and subcutaneous tissue caused by M...
Buruli ulcer (BU) is an emerging necrotizing disease of the skin and subcutaneous tissue caused by M...
International audienceCurrently, there are only two publicly available genomes of Mycobacte-rium ulc...
BACKGROUND: Increased availability of Next Generation Sequencing (NGS) techniques allows, for the fi...
Mycobacterium ulcerans causes Buruli ulcer, an ulcer-ative skin disease in tropical and subtropical ...
Mycobacterium ulcerans causes the devastating infectious skin disease Buruli ulcer and has a monomor...
Elucidation of the transmission, epidemiology, and evolution of Mycobacterium ulcerans, the causativ...
Elucidation of the transmission, epidemiology, and evolution of Mycobacterium ulcerans, the causativ...
Elucidation of the transmission, epidemiology, and evolution of Mycobacterium ulcerans, the causativ...
Mycobacterium ulcerans is the causative agent of Buruli ulcer, the third most common mycobacterial d...
<div><p>Background</p><p><i>Mycobacterium ulcerans</i> is the causative agent of the necrotizing ski...
Buruli ulcer is an emerging and neglected tropical disease caused byMycobacterium ulcer-ans. Few cas...
International audienceBuruli ulcer (BU), the third most frequent mycobacteriosis worldwide, is a neg...
Buruli Ulcer (BU), caused by Mycobacterium ulcerans, is the third most common mycobacteriosis worldw...
International audienceBuruli ulcer, caused by Mycobacterium ulcerans and characterized by devastatin...
Buruli ulcer (BU) is an emerging necrotizing disease of the skin and subcutaneous tissue caused by M...
Buruli ulcer (BU) is an emerging necrotizing disease of the skin and subcutaneous tissue caused by M...
International audienceCurrently, there are only two publicly available genomes of Mycobacte-rium ulc...
BACKGROUND: Increased availability of Next Generation Sequencing (NGS) techniques allows, for the fi...
Mycobacterium ulcerans causes Buruli ulcer, an ulcer-ative skin disease in tropical and subtropical ...
Mycobacterium ulcerans causes the devastating infectious skin disease Buruli ulcer and has a monomor...
Elucidation of the transmission, epidemiology, and evolution of Mycobacterium ulcerans, the causativ...
Elucidation of the transmission, epidemiology, and evolution of Mycobacterium ulcerans, the causativ...
Elucidation of the transmission, epidemiology, and evolution of Mycobacterium ulcerans, the causativ...
Mycobacterium ulcerans is the causative agent of Buruli ulcer, the third most common mycobacterial d...
<div><p>Background</p><p><i>Mycobacterium ulcerans</i> is the causative agent of the necrotizing ski...
Buruli ulcer is an emerging and neglected tropical disease caused byMycobacterium ulcer-ans. Few cas...