Opioids represent a highly-abused and highly potent class of drugs that have become a significant threat to public safety. Often there are little to no pharmacological and toxicological data available for new, illicitly used and abused opioids, and this has resulted in a growing number of serious adverse events, including death. The large influx of new synthetic opioids permeating the street-drug market, including fentanyl and fentanyl analogs, has generated the need for a fast and effective method to evaluate the risk a substance poses to public safety. In response, the US FDA's Center for Drug Evaluation and Research (CDER) has developed a rapidly-deployable, multi-pronged computational approach to assess a drug's risk to public health. A...
The abuse of novel psychoactive substances (NPS) has risen dramatically worldwide, especially among ...
By binding to and activating the G-protein coupled μ−, κ− and δ−opioid receptors in the central nerv...
Currently, opioids are extensively used in clinical practices in order to treat pain in patients. Ho...
<div><p>Opioids represent a highly-abused and highly potent class of drugs that have become a signif...
Three quantitative structure-activity relationship (QSAR) models for predicting the affinity of mu-o...
<p>Scatterplot of the experimentally determined binding affinity, K<sub>i</sub>, with the ADS from t...
<p>Scatterplot of the experimentally determined binding affinity, K<sub>i</sub>, with the average do...
<p>The 8 fentanyl derivatives and 7 fentanyl congeners are listed first and ordered by increasing bi...
In 1960, Dr. Paul Janssen of the Janssen Company synthesized fentanyl. It is a rapid-acting analgesi...
Fentanyl is a highly potent and clinically widely used narcotic analgesic. The synthesis of its anal...
Abstract Opioids are essential pharmaceuticals due to their analgesic properties, however, lethal si...
Fentanyl analogs represent an important group of new psychoactive substances and knowing their effic...
Fentanyl and morphine are agonists of the Mu opioid receptor (MOR), which is a member of the GPCR fa...
Today, more Americans die each year because of drug overdoses than are killed in motor vehicle accid...
Fentanyl derivatives (FENS) belongs to the class of Novel Synthetic Opioids that emerged in the ille...
The abuse of novel psychoactive substances (NPS) has risen dramatically worldwide, especially among ...
By binding to and activating the G-protein coupled μ−, κ− and δ−opioid receptors in the central nerv...
Currently, opioids are extensively used in clinical practices in order to treat pain in patients. Ho...
<div><p>Opioids represent a highly-abused and highly potent class of drugs that have become a signif...
Three quantitative structure-activity relationship (QSAR) models for predicting the affinity of mu-o...
<p>Scatterplot of the experimentally determined binding affinity, K<sub>i</sub>, with the ADS from t...
<p>Scatterplot of the experimentally determined binding affinity, K<sub>i</sub>, with the average do...
<p>The 8 fentanyl derivatives and 7 fentanyl congeners are listed first and ordered by increasing bi...
In 1960, Dr. Paul Janssen of the Janssen Company synthesized fentanyl. It is a rapid-acting analgesi...
Fentanyl is a highly potent and clinically widely used narcotic analgesic. The synthesis of its anal...
Abstract Opioids are essential pharmaceuticals due to their analgesic properties, however, lethal si...
Fentanyl analogs represent an important group of new psychoactive substances and knowing their effic...
Fentanyl and morphine are agonists of the Mu opioid receptor (MOR), which is a member of the GPCR fa...
Today, more Americans die each year because of drug overdoses than are killed in motor vehicle accid...
Fentanyl derivatives (FENS) belongs to the class of Novel Synthetic Opioids that emerged in the ille...
The abuse of novel psychoactive substances (NPS) has risen dramatically worldwide, especially among ...
By binding to and activating the G-protein coupled μ−, κ− and δ−opioid receptors in the central nerv...
Currently, opioids are extensively used in clinical practices in order to treat pain in patients. Ho...