Background: Although several studies link high levels of IL-6 and soluble IL-6 receptor (sIL-6R) with asthma severity and decreased lung function, the role of IL-6 trans-signaling (IL-6TS) in asthma is unclear. Objective: To explore the association between epithelial IL-6TS pathway activation and molecular and clinical phenotypes in asthma. Methods: An IL-6TS gene signature, obtained from air-liquid interface (ALI) cultures of human bronchial epithelial cells stimulated with IL-6 and sIL-6R, was used to stratify lung epithelium transcriptomic data (U-BIOPRED cohorts) by hierarchical clustering. IL-6TS-specific protein markers were used to stratify sputum biomarker data (Wessex cohort). Molecular phenotyping was based on transcriptional ...
The cytokine IL-6 acts via a specific receptor complex that consists of the membrane-bound IL-6 rece...
The cytokine IL-6 acts via a specific receptor complex that consists of the membrane-bound IL-6 rece...
Asthma is a common inflammatory disease of the airway caused by a combination of genetic and environ...
Background: Although several studies link high levels of IL-6 and soluble IL-6 receptor (sIL-6R) wit...
Background: Although several studies link high levels of IL-6 and soluble IL-6 receptor (sIL-6R) wit...
BACKGROUND Although several studies link high levels of IL-6 and soluble IL-6 receptor (sIL-6R) t...
BACKGROUND: Although several studies link high levels of IL-6 and soluble IL-6 receptor (sIL-6R) wit...
Background: Although several studies link high levels of IL-6 and soluble IL-6 receptor (sIL-6R) wit...
Background Although several studies link high levels of IL-6 and soluble IL-6 receptor (sIL-6R) with...
Background: Although several studies link high levels of IL-6 and soluble IL-6 receptor (sIL-6R) to ...
Background: Although several studies link high levels of IL-6 and soluble IL-6 receptor (sIL-6R) to ...
Background: Although several studies link high levels of IL-6 and soluble IL-6 receptor (sIL-6R) to ...
Background: Although several studies link high levels of IL-6 and soluble IL-6 receptor (sIL-6R) to ...
Background: Although several studies link high levels of IL-6 and soluble IL-6 receptor (sIL-6R) to ...
Background: Although several studies link high levels of IL-6 and soluble IL-6 receptor (sIL-6R) to ...
The cytokine IL-6 acts via a specific receptor complex that consists of the membrane-bound IL-6 rece...
The cytokine IL-6 acts via a specific receptor complex that consists of the membrane-bound IL-6 rece...
Asthma is a common inflammatory disease of the airway caused by a combination of genetic and environ...
Background: Although several studies link high levels of IL-6 and soluble IL-6 receptor (sIL-6R) wit...
Background: Although several studies link high levels of IL-6 and soluble IL-6 receptor (sIL-6R) wit...
BACKGROUND Although several studies link high levels of IL-6 and soluble IL-6 receptor (sIL-6R) t...
BACKGROUND: Although several studies link high levels of IL-6 and soluble IL-6 receptor (sIL-6R) wit...
Background: Although several studies link high levels of IL-6 and soluble IL-6 receptor (sIL-6R) wit...
Background Although several studies link high levels of IL-6 and soluble IL-6 receptor (sIL-6R) with...
Background: Although several studies link high levels of IL-6 and soluble IL-6 receptor (sIL-6R) to ...
Background: Although several studies link high levels of IL-6 and soluble IL-6 receptor (sIL-6R) to ...
Background: Although several studies link high levels of IL-6 and soluble IL-6 receptor (sIL-6R) to ...
Background: Although several studies link high levels of IL-6 and soluble IL-6 receptor (sIL-6R) to ...
Background: Although several studies link high levels of IL-6 and soluble IL-6 receptor (sIL-6R) to ...
Background: Although several studies link high levels of IL-6 and soluble IL-6 receptor (sIL-6R) to ...
The cytokine IL-6 acts via a specific receptor complex that consists of the membrane-bound IL-6 rece...
The cytokine IL-6 acts via a specific receptor complex that consists of the membrane-bound IL-6 rece...
Asthma is a common inflammatory disease of the airway caused by a combination of genetic and environ...